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  • Thymosin Alpha-1 5MG 10MG
  • Thymosin Alpha-1 5MG 10MG

Thymosin Alpha-1 5MG 10MG

The peptide will be provided as lyophilized powder to ensure maximum stability.
Thymosin Alpha-1 is a biologically active peptide naturally derived from the thymus, composed of 28 amino acids. It possesses remarkable immune regulatory properties. By precisely activating T-cell differentiation and maturation, it significantly enhances the body's Th1-type immune response, helping to effectively identify and eliminate pathogens and abnormal cells. In conditions such as chronic hepatitis, immunodeficiency, and infectious diseases, Thymosin Alpha-1 rapidly restores immune balance while enhancing the effectiveness of vaccinations, providing a robust boost to the immune system.
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  • Detail

    Research Peptide · For Laboratory Use Only

    Thymosin Alpha-1 10mg

    Tα1 · Thymalfasin · 28-Amino-Acid Immunomodulatory Peptide · Lyophilized Powder · Purity ≥98% (HPLC)

    Thymosin Alpha-1 (Tα1, also known as thymalfasin) is a naturally occurring, heat-stable, highly acidic peptide of 28 amino acids, originally isolated from thymosin fraction 5 of thymus tissue. It is cleaved from the precursor protein prothymosin alpha and has long been recognized for modifying, enhancing and restoring immune function.

    Our synthetic Tα1 carries an N-terminal acetyl group and is identical in sequence to human thymosin alpha-1. Each vial is supplied as a sterile lyophilized (freeze-dried) powder to ensure maximum stability.

    Product Specifications

    Product Name Thymosin Alpha-1 (Tα1, Thymalfasin)
    CAS Number 62211-93-2 (thymalfasin registry: 62304-98-7)
    Amino Acid Sequence Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH (single-letter: Ac-SDAAVDTSS EITTKDLKEKK EVVEEAEN, 28 residues)
    Molecular Formula C₁₂₉H₂₁₅N₃₃O₅₅
    Molecular Weight 3108.3 g/mol
    Quantity 10mg per vial
    Physical Form White to off-white lyophilized powder
    Purity ≥98% as determined by HPLC
    Storage -20°C for long term; 2–8°C for short term (lyophilized)

    What is Thymosin Alpha-1?

    The thymus gland produces a family of hormones and peptides that orchestrate the development and function of T lymphocytes. Among them, Thymosin Alpha-1 — first isolated and sequenced by Goldstein and colleagues in 1977 — is one of the best characterized and most extensively studied thymic peptides, with a literature spanning several decades.

    Unlike crude thymus extracts, Tα1 is a chemically defined single molecule: a 28-amino-acid acetylated polypeptide whose sequence is identical to the human form. This precise structure makes it a highly reproducible research compound.

    In published research, Tα1 has been investigated in a wide range of settings, including:

    • Immune dysfunction, immunodeficiency and immune-aging (immunosenescence) research;
    • Chronic viral infection models (notably hepatitis B and C studies);
    • Oncology research, frequently studied as an immune-modulating adjunct alongside chemotherapy;
    • Vaccine response studies, where Tα1 has been explored as an immune response modifier.

    Tα1 is approved as an immunomodulatory drug in multiple countries (marketed as Zadaxin® / thymalfasin), which has made it one of the most clinically documented peptides in the thymic peptide family and a reference compound in immunology research.

    Mechanism of Action

    1. Promotion of T-Cell Maturation & Differentiation

    Tα1 stimulates the maturation of T lymphocytes and promotes the differentiation of T-cell subsets, helping to restore balanced T-cell populations in states of immune suppression.

    2. Upregulation of Cytokine Production

    In vitro studies show that Tα1 increases the production of interferon-α, interferon-γ, interleukin-2 and interleukin-3 by activated T cells, and raises lymphokine receptor expression on T-cell surfaces.

    3. Activation of CD4⁺ T Cells & NK Cells

    Research reports that Tα1 enhances CD4⁺ T-cell activation and promotes the accumulation and cytotoxicity of natural killer (NK) cell precursors, strengthening both adaptive and innate immune surveillance.

    4. Dendritic Cell & Antigen Presentation Effects

    Tα1 has been shown to modulate dendritic cell function and antigen presentation, linking innate recognition with adaptive T-cell responses — a key reason it is studied in vaccine-adjuvant and anti-infection research.

    5. Immune Homeostasis Rather Than Stimulation

    A distinctive feature of Tα1 is its regulatory character: rather than acting as a simple immune stimulant, it tends to normalize dysregulated immune responses, which underlies its broad research use across infection, oncology and autoimmunity models.

    Handling & Storage Guidelines

    • Lyophilized powder: Store at -20°C for long-term stability; 2–8°C is acceptable for short-term storage. Avoid repeated temperature cycling and protect from light.
    • Before opening: Allow the vial to reach room temperature and briefly centrifuge to ensure the full contents collect at the bottom of the vial.
    • Reconstitution: Add bacteriostatic water or an appropriate solvent gently along the vial wall. Swirl slowly until fully dissolved; avoid vigorous shaking.
    • Reconstituted solution: Store at 2–8°C and use within the validated stability window; do not refreeze the solution.
    • General: Handle with standard laboratory protective equipment (gloves, lab coat, eye protection).

    Why Choose Our Thymosin Alpha-1?

    🧪

    Verified Purity

    Each batch tested by HPLC & MS; COA available upon request.

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    Secure Packaging

    Sealed vials with temperature-protective packaging for safe delivery.

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    Fast Dispatch

    Orders processed promptly with tracking provided.

    Frequently Asked Questions

    Q1: What is the difference between Thymosin Alpha-1 and TB-500?

    A: Although both are named after thymosins, they are different molecules with different research profiles. Thymosin Alpha-1 is a 28-amino-acid immunomodulatory peptide derived from prothymosin alpha, studied mainly in immunity research. TB-500 is a fragment of thymosin beta-4, studied mainly in tissue repair and cell migration research.

    Q2: What is the difference between Tα1 and Thymalin?

    A: Tα1 is a chemically defined single 28-amino-acid peptide. Thymalin is a thymus-derived peptide complex (a bioregulator containing multiple short peptides). They are related thymic preparations but are not the same product.

    Q3: How should I store it after receiving?

    A: Keep unopened vials at -20°C for long-term storage. Once reconstituted, refrigerate at 2–8°C and use promptly; do not refreeze the solution.

    Q4: Is a Certificate of Analysis (COA) available?

    A: Yes, third-party tested COA documentation can be provided for each batch. Please contact our customer service with your order number.

    ⚠ Research Use Only — Disclaimer

    All product information provided on this page is solely for information dissemination and educational purposes. The products offered are intended exclusively for in vitro laboratory research and are not pharmaceuticals. They have not been approved by the U.S. Food and Drug Administration (FDA) or any other regulatory authority for the purposes sold here, and must not be used to prevent, treat or cure any medical condition, disease or ailment.

    It is strictly prohibited to introduce these products into the human or animal body in any form. By purchasing, the buyer acknowledges full responsibility for the proper handling, use and compliance with all applicable local laws and regulations.

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