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  • TB-500 5MG 10MG
  • TB-500 5MG 10MG

TB-500 5MG 10MG

The peptide will be provided as lyophilized powder to ensure maximum stability.
TB-500, a synthetic analog of Thymosin Beta-4 (Tβ4), promotes tissue repair and regeneration by regulating actin dynamics and stimulating cell migration, proliferation, and differentiation.TB-500 is a functional fragment of thymosin β4 primarily used to study mechanisms related to cell migration and tissue repair. Its actions focus on promoting cell motility, supporting tissue structural reconstruction, and participating in repair signal regulation. Research indicates that TB-500 is closely associated with cytoskeletal regulation, particularly influencing actin dynamics. Its mechanism enhances the coordination of tissue repair processes by modulating cell migration-related signaling pathways. TB-500 holds significant research value in the fields of tissue regeneration, injury repair, and cell migration studies.
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  • Detail

    Research Peptide · For Laboratory Use Only

    TB-500 10mg

    Synthetic Analog of Thymosin Beta-4 (Tβ4) · Lyophilized Powder · Purity ≥99% (HPLC)

    TB-500 is a synthetic analog of Thymosin Beta-4 (Tβ4), the principal active fragment of the naturally occurring thymosin β4 protein. By regulating actin dynamics, it promotes cell migration, proliferation and differentiation, and has become a widely studied research tool in the fields of tissue repair, cell biology and regenerative medicine.

    Each vial is supplied as a sterile lyophilized (freeze-dried) powder to ensure maximum stability and long-term integrity during storage and transport.

    Product Specifications

    Product Name TB-500 (Thymosin Beta-4 Fragment)
    CAS Number 885340-08-9
    Amino Acid Sequence LKKTETQ
    Molecular Formula C₃₈H₆₈N₁₀O₁₄
    Molecular Weight 889.0 g/mol
    Quantity 10mg per vial
    Physical Form White lyophilized powder
    Purity ≥98% as determined by HPLC
    Storage -20°C for long term; 2–8°C for short term (lyophilized)

    What is TB-500?

    TB-500 is a polypeptide with broad biological activities, derived from the active site of thymosin β4. By regulating the dynamic equilibrium of actin — a core component of the cellular cytoskeleton — it promotes cell migration, proliferation and differentiation, thereby playing a significant role in tissue repair and regeneration research.

    In published studies, TB-500 has been investigated in connection with:

    • Wound closure, collagen deposition and reduced scar formation in skin models;
    • Anti-inflammatory signaling in chronic inflammation research;
    • Neovascularization and cardiomyocyte protection after myocardial injury;
    • Cell migration mechanisms in regenerative medicine studies.

    Featuring high efficiency, multifunctionality and excellent biocompatibility in research settings, TB-500 has become a hot topic in cardiovascular repair, neuroprotection and chronic inflammation research.

    Mechanism of Action

    1. Regulation of Actin Dynamics

    TB-500 is closely associated with cytoskeletal regulation. By modulating actin dynamics, it enhances the coordination of cell migration-related signaling pathways, which is fundamental to tissue repair processes.

    2. Activation of Cell Signaling Pathways

    Research suggests TB-500 may activate signaling pathways related to cell growth and repair, such as the PI3K/Akt pathway, stimulating cell proliferation and differentiation to support tissue regeneration.

    3. Extracellular Matrix Regulation

    TB-500 is believed to promote collagen deposition and regulate the synthesis and degradation of the extracellular matrix, supporting cell adhesion, migration and tissue remodeling.

    4. Anti-inflammatory Activity

    TB-500 may inhibit the production of inflammatory mediators such as TNF-α and IL-1β and modulate immune cell function, creating a more favorable environment for tissue repair.

    5. Promotion of Angiogenesis

    TB-500 may promote angiogenesis, increasing blood supply to damaged tissues and providing nutrients and oxygen that facilitate the repair process.

    Handling & Storage Guidelines

    • Lyophilized powder: Store at -20°C for long-term stability (12–24 months); 2–8°C is acceptable for short-term storage (weeks).
    • Before opening: Allow the vial to reach room temperature and briefly centrifuge to ensure the full contents collect at the bottom.
    • Reconstitution: Add bacteriostatic water or an appropriate solvent gently along the vial wall. Avoid vigorous shaking; swirl slowly until fully dissolved.
    • Reconstituted solution: Store at 2–8°C and use within the validated stability window; avoid repeated freeze-thaw cycles.
    • General: Handle with standard laboratory protective equipment (gloves, lab coat, eye protection).

    Why Choose Our TB-500?

    🧪

    Verified Purity

    Each batch tested by HPLC & MS; COA available upon request.

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    Secure Packaging

    Sealed vials with temperature-protective packaging for safe delivery.

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    Fast Dispatch

    Orders processed promptly with tracking provided.

    Frequently Asked Questions

    Q1: What form does TB-500 come in?

    A: It is supplied as a sterile white lyophilized powder, which provides superior stability compared with liquid form.

    Q2: How should I store it after receiving?

    A: Keep unopened vials at -20°C for long-term storage. Once reconstituted, refrigerate at 2–8°C and use promptly; do not refreeze the solution.

    Q3: Is a Certificate of Analysis (COA) available?

    A: Yes, third-party tested COA documentation can be provided for each batch. Please contact our customer service with your order number.

    ⚠ Research Use Only — Disclaimer

    All product information provided on this page is solely for information dissemination and educational purposes. The products offered are intended exclusively for in vitro laboratory research and are not pharmaceuticals. They have not been approved by the U.S. Food and Drug Administration (FDA) or any other regulatory authority, and must not be used to prevent, treat or cure any medical condition, disease or ailment.

    It is strictly prohibited to introduce these products into the human or animal body in any form. By purchasing, the buyer acknowledges full responsibility for the proper handling, use and compliance with all applicable local laws and regulations.

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