Snap-8 10mg
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Detail
Cosmetic Peptide · For Laboratory Use Only
Snap-8 10mg
Acetyl Octapeptide-3 · Argireline®-Derived Anti-Wrinkle Peptide · Lyophilized Powder · Purity ≥99% (HPLC)
Snap-8 (INCI name: Acetyl Octapeptide-3) is a next-generation anti-wrinkle peptide derived from the hexapeptide Argireline®. Its sequence — Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ — was rationally extended by two amino acids to enhance interaction with the SNARE complex, the molecular machinery responsible for neurotransmitter release.
By modulating SNARE complex formation in a manner similar to botulinum toxin type A but far milder and fully topical, Snap-8 helps reduce the depth of expression wrinkles caused by repeated facial muscle contraction — earning it the nickname "topical botox" in cosmetic science. Each vial is supplied as a sterile lyophilized (freeze-dried) powder to ensure maximum stability.
Product Specifications
Product Name Snap-8 (Acetyl Octapeptide-3) CAS Number 868844-74-0 Amino Acid Sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ (Ac-EEMQRRAD-NH₂, 8 residues) Molecular Formula C₄₁H₇₀N₁₆O₁₆S Molecular Weight 1075.16 g/mol Quantity 5mg per vial Physical Form White lyophilized powder Purity ≥99% as determined by HPLC Solubility Soluble in water and aqueous buffers Storage -20°C for long term; 2–8°C for short term (lyophilized) What is Snap-8?
Expression wrinkles — crow's feet, forehead lines, laugh lines — form because repeated muscle contractions fold the skin in the same places over many years. The contraction signal is transmitted at the neuromuscular junction through the SNARE complex, a protein assembly that enables vesicles to release the neurotransmitter acetylcholine.
Snap-8 is a synthetic octapeptide modeled on a region of the SNAP-25 protein, one of the three components of the SNARE complex. By mimicking this fragment, Snap-8 competes with native SNAP-25 and mildly destabilizes the complex, which reduces neurotransmitter release and softens muscle contraction — without paralysis, without injections, and without altering natural facial expression.
In cosmetic research and formulation studies, Snap-8 has been investigated for:
- Reduction of expression wrinkle depth, with profilometry studies reporting measurable wrinkle reduction within 28 days of topical use;
- Anti-aging serums, creams and eye-area formulations;
- Controlled-release delivery systems (nanoparticles, microneedle patches) for enhanced peptide penetration;
- Comparative research on neurotransmitter-inhibiting peptides as cosmetic actives.
As an evolution of the well-established Argireline® peptide, Snap-8 represents one of the most studied non-invasive approaches to smoothing expression lines, widely used in high-end anti-wrinkle cosmetics worldwide.
Mechanism of Action
Handling & Storage Guidelines
- Lyophilized powder: Store at -20°C for long-term stability; 2–8°C is acceptable for short-term storage (up to one week). Avoid repeated temperature cycling and protect from moisture.
- Before opening: Allow the vial to reach room temperature and briefly centrifuge to ensure the full contents collect at the bottom.
- Reconstitution: Snap-8 dissolves readily in water or aqueous buffer. Add solvent gently along the vial wall and swirl slowly until fully dissolved; avoid vigorous shaking.
- Reconstituted solution: Aliquot for multiple use and store at -20°C; avoid repeated freeze-thaw cycles.
- Formulation note: In cosmetic research, Snap-8 is typically incorporated into water-phase formulations at pH 4–7 to preserve peptide integrity.
Why Choose Our Snap-8?
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Verified Purity
Each batch tested by HPLC & MS; COA available upon request.
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Secure Packaging
Sealed vials with temperature-protective packaging for safe delivery.
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Fast Dispatch
Orders processed promptly with tracking provided.
Frequently Asked Questions
Q1: What is the difference between Snap-8 and Argireline®?
A: Argireline® (Acetyl Hexapeptide-8/3) is a hexapeptide; Snap-8 is its octapeptide evolution, extended by two amino acids (Ala-Asp). The longer sequence is designed to interact more effectively with the SNARE complex, which is why Snap-8 is generally regarded as the more potent of the two in cosmetic research.
Q2: Does Snap-8 work like Botox?
A: Snap-8 shares a conceptual similarity with botulinum toxin — both act on the neurotransmitter release machinery — but the mechanisms differ fundamentally. Snap-8 mildly and reversibly modulates SNARE complex formation through topical application; it does not cleave proteins, does not cause paralysis, and is not an injectable.
Q3: How should I store it after receiving?
A: Keep unopened vials at -20°C for long-term storage. Once reconstituted, aliquot and store at -20°C; avoid repeated freeze-thaw cycles.
Q4: Is a Certificate of Analysis (COA) available?
A: Yes, third-party tested COA documentation can be provided for each batch. Please contact our customer service with your order number.
⚠ Research Use Only — Disclaimer
All product information provided on this page is solely for information dissemination and educational purposes. The products offered are intended exclusively for laboratory research and cosmetic formulation research and are not pharmaceuticals. They have not been approved by the U.S. Food and Drug Administration (FDA) or any other regulatory authority for the purposes sold here, and must not be used to prevent, treat or cure any medical condition, disease or ailment.
It is strictly prohibited to introduce these products into the human or animal body in any form. By purchasing, the buyer acknowledges full responsibility for the proper handling, use and compliance with all applicable local laws and regulations.
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