Slupp-332 5MG
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Detail
Small-Molecule Research Compound · For Laboratory Use Only
SLU-PP-332 5mg
Pan-ERR (ERRα/β/γ) Agonist · "Exercise Mimetic" Research Compound · Purity ≥99% (HPLC)
SLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptors (ERRs) — orphan nuclear receptors that act as master regulators of cellular energy metabolism. Developed in the Burris laboratory, it activates all three ERR subtypes (ERRα, ERRβ and ERRγ), with the highest affinity for ERRα (reported EC₅₀ values of approximately 98, 230 and 430 nM, respectively).
In published research, SLU-PP-332 has been described as an "exercise mimetic": in mouse studies it triggered many of the metabolic adaptations normally induced by endurance training — increased oxidative muscle fibers, enhanced fatty acid oxidation and improved exercise capacity — making it one of the most talked-about research compounds in metabolic and exercise biology. Each vial is supplied as a white to off-white solid powder.
Product Specifications
Product Name SLU-PP-332 (also searched as SLUPP-332) CAS Number 303760-60-3 Chemical Name 4-Hydroxy-N-[(E)-naphthalen-2-ylmethylideneamino]benzamide Molecular Formula C₁₈H₁₄N₂O₂ Molecular Weight 290.32 g/mol Target Profile Pan-ERR agonist: ERRα (EC₅₀ ≈ 98 nM), ERRβ (≈ 230 nM), ERRγ (≈ 430 nM) Quantity 5mg per vial Physical Form White to off-white solid powder Purity ≥99% as determined by HPLC Storage -20°C for long term; 2–8°C for short term; keep sealed, dry and protected from light What is SLU-PP-332?
Regular endurance exercise reprograms skeletal muscle: mitochondria multiply, oxidative (type IIa) muscle fibers expand, and the body shifts toward burning fat for fuel. A major part of this adaptation is controlled by the estrogen-related receptors (ERRs) — despite their name, ERRs do not bind estrogen; they are orphan nuclear receptors that orchestrate mitochondrial biogenesis, oxidative phosphorylation, fatty acid oxidation and the tricarboxylic acid cycle, especially in high-energy tissues such as skeletal muscle, heart, liver and brain.
For years, designing a potent ERRα agonist proved difficult. SLU-PP-332 changed that. Reported by the Burris group (University of Florida / Washington University in St. Louis), it is an orally available small molecule that activates all three ERR subtypes with highest potency at ERRα, and possesses pharmacokinetic properties suitable for in vivo research.
In published preclinical studies, SLU-PP-332 has been investigated in a wide range of settings:
- Exercise capacity: dosed mice showed an increased proportion of type IIa oxidative muscle fibers and markedly improved treadmill endurance (running time and distance increases reported in the range of tens of percent);
- Body composition: obese mice given SLU-PP-332 lost weight and fat mass on the same food intake, without an exercise program;
- Metabolic syndrome: a 2024 study reported that SLU-PP-332 mimics exercise-induced benefits on whole-body metabolism — increased energy expenditure and fatty acid oxidation — and alleviated features of metabolic syndrome in mouse models;
- Muscle & aging research: ERR signaling is being explored as a target for age-related muscle decline and metabolic dysfunction.
Together, these findings positioned SLU-PP-332 as a leading "exercise mimetic" research compound — a chemical tool that reproduces key molecular and metabolic signatures of aerobic exercise, and a benchmark molecule for the rapidly growing ERR pharmacology field.
Mechanism of Action
Handling & Storage Guidelines
- Powder form: Store at -20°C for long-term stability; 2–8°C is acceptable for short-term storage. Keep the vial tightly sealed, dry and protected from light.
- Before opening: Allow the vial to reach room temperature and briefly centrifuge to ensure the full contents collect at the bottom.
- Stock solution: As a small molecule, SLU-PP-332 is typically dissolved in an appropriate organic solvent for in vitro work (prepare fresh or aliquot and freeze; avoid repeated freeze-thaw cycles). Please refer to the batch datasheet for validated solubility conditions.
- Working solutions: Dilute stock solutions into assay medium as required by your experimental design; use promptly after preparation.
- General: Handle with standard laboratory protective equipment (gloves, lab coat, eye protection).
Why Choose Our SLU-PP-332?
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Verified Purity
Each batch tested by HPLC & MS; COA available upon request.
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Secure Packaging
Sealed vials with protective packaging for safe delivery.
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Fast Dispatch
Orders processed promptly with tracking provided.
Frequently Asked Questions
Q1: Is SLU-PP-332 a peptide?
A: No. Unlike many compounds in our catalog, SLU-PP-332 is a synthetic small molecule (MW ≈ 290 Da), not a peptide. It is an orally available ERR agonist, supplied as a solid powder.
Q2: What does "exercise mimetic" mean?
A: It is a research term for compounds that reproduce some of the molecular and metabolic adaptations normally triggered by exercise — in SLU-PP-332's case, through activation of ERR-driven gene programs in skeletal muscle (oxidative fiber shift, fatty acid oxidation, higher energy expenditure). The term describes preclinical research findings and does not imply any approved use.
Q3: How should I store it after receiving?
A: Keep the sealed vial at -20°C for long-term storage or 2–8°C for short-term use; protect from moisture and light. Prepared solutions should be aliquoted and frozen to avoid repeated freeze-thaw cycles.
Q4: Is a Certificate of Analysis (COA) available?
A: Yes, third-party tested COA documentation can be provided for each batch. Please contact our customer service with your order number.
⚠ Research Use Only — Disclaimer
All product information provided on this page is solely for information dissemination and educational purposes. The products offered are intended exclusively for in vitro laboratory research and are not pharmaceuticals. They have not been approved by the U.S. Food and Drug Administration (FDA) or any other regulatory authority for the purposes sold here, and must not be used to prevent, treat or cure any medical condition, disease or ailment.
It is strictly prohibited to introduce these products into the human or animal body in any form. By purchasing, the buyer acknowledges full responsibility for the proper handling, use and compliance with all applicable local laws and regulations.
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