Semax 5mg 10mg
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Detail
Research Peptide · For Laboratory Use Only
Semax 10mg
ACTH(4–10) Analog · Neuroprotective Heptapeptide · Lyophilized Powder · Purity ≥99% (HPLC)
Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It was designed as an analog of the adrenocorticotropic hormone fragment ACTH(4–10), with key amino acid substitutions that remove all hormonal (melanocortin/steroidogenic) activity while preserving and enhancing its neurotropic effects.
Developed at the Russian Academy of Sciences' Institute of Molecular Genetics, Semax has been studied for decades in neuroprotection, cognitive enhancement and acute stroke research, and is one of the most extensively documented neuroactive peptides in the literature. Each vial is supplied as a sterile lyophilized (freeze-dried) powder to ensure maximum stability.
Product Specifications
Product Name Semax (ACTH(4–10) Analog) CAS Number 80714-61-0 Amino Acid Sequence Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP, 7 residues; parent fragment ACTH(4–10): Met-Glu-His-Phe-Arg-Trp-Gly) Molecular Formula C₃₇H₅₁N₉O₁₀S Molecular Weight 813.92 g/mol Hormonal Activity None — substitutions eliminate ACTH-related steroidogenic/melanocortin activity Quantity 10mg per vial Physical Form White to off-white lyophilized powder Purity ≥99% as determined by HPLC Storage -20°C for long term; 2–8°C for short term (lyophilized) What is Semax?
Adrenocorticotropic hormone (ACTH) is best known for stimulating cortisol production, but its N-terminal fragments also exert powerful effects on the brain that are independent of steroidogenic signaling. The ACTH(4–10) fragment (Met-Glu-His-Phe-Arg-Trp-Gly) was shown to influence attention, memory and learning — yet it is rapidly degraded in vivo.
Semax solves this problem through rational design: by replacing the C-terminal segment Arg⁸-Trp⁹-Gly¹⁰ of ACTH(4–10) with the Pro-Gly-Pro tripeptide, researchers created a molecule that retains the neurotropic profile of ACTH(4–10) while gaining markedly improved metabolic stability and no hormonal activity whatsoever.
In published research, Semax has been investigated in a wide range of settings, including:
- Acute ischemic stroke — Semax has been used successfully in stroke therapy research in Russia;
- Cognitive enhancement and nootropic research (attention, learning, memory);
- Neuroprotection in models of hypoxia, excitotoxicity and neurodegeneration;
- BDNF/trkB signaling studies, where Semax has been reported to regulate brain-derived neurotrophic factor expression in the hippocampus;
- Basal forebrain cholinergic neuron research, relevant to Alzheimer's disease models.
With decades of preclinical and clinical literature behind it, Semax stands as one of the most thoroughly studied neuroactive peptides — a benchmark compound for research into neurotrophic modulation and cognitive pharmacology.
Mechanism of Action
Handling & Storage Guidelines
- Lyophilized powder: Store at -20°C for long-term stability; 2–8°C is acceptable for short-term storage. Avoid repeated temperature cycling and protect from moisture.
- Before opening: Allow the vial to reach room temperature and briefly centrifuge to ensure the full contents collect at the bottom of the vial.
- Reconstitution: Semax dissolves readily in water or physiological saline. Add solvent gently along the vial wall and swirl slowly until fully dissolved; avoid vigorous shaking.
- Reconstituted solution: Store at 2–8°C and use promptly; aliquot if needed and avoid repeated freeze-thaw cycles.
- General: Handle with standard laboratory protective equipment (gloves, lab coat, eye protection).
Why Choose Our Semax?
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Verified Purity
Each batch tested by HPLC & MS; COA available upon request.
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Secure Packaging
Sealed vials with temperature-protective packaging for safe delivery.
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Fast Dispatch
Orders processed promptly with tracking provided.
Frequently Asked Questions
Q1: Does Semax have any hormonal activity like ACTH?
A: No. Although Semax is derived from the ACTH(4–10) fragment, the C-terminal segment Arg⁸-Trp⁹-Gly¹⁰ has been replaced with the Pro-Gly-Pro tripeptide, which completely eliminates ACTH-related steroidogenic and melanocortin activity. Semax acts on the nervous system, not on adrenal hormone production.
Q2: What is the difference between Semax and Selank?
A: Both are synthetic analogs of hormone fragments developed by the same Russian research program, but they serve different research purposes. Semax is an ACTH(4–10) analog studied mainly for neuroprotection and cognition, while Selank is a tuftsin analog studied mainly for anxiolytic (anti-anxiety) effects.
Q3: How should I store it after receiving?
A: Keep unopened vials at -20°C for long-term storage. Once reconstituted, refrigerate at 2–8°C and use promptly; aliquot and avoid repeated freeze-thaw cycles.
Q4: Is a Certificate of Analysis (COA) available?
A: Yes, third-party tested COA documentation can be provided for each batch. Please contact our customer service with your order number.
⚠ Research Use Only — Disclaimer
All product information provided on this page is solely for information dissemination and educational purposes. The products offered are intended exclusively for in vitro laboratory research and are not pharmaceuticals. They have not been approved by the U.S. Food and Drug Administration (FDA) or any other regulatory authority for the purposes sold here, and must not be used to prevent, treat or cure any medical condition, disease or ailment.
It is strictly prohibited to introduce these products into the human or animal body in any form. By purchasing, the buyer acknowledges full responsibility for the proper handling, use and compliance with all applicable local laws and regulations.
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