Home / Selank 5MG 10MG
  • Selank 5MG 10MG
  • Selank 5MG 10MG

Selank 5MG 10MG

The peptide will be provided as lyophilized powder to ensure maximum stability.
Selank is a synthetic peptide product developed based on natural regulatory peptide cluster proteins, scientifically proven to comprehensively enhance nervous, immune, and cognitive health. It effectively alleviates anxiety and stress, regulates emotional balance, reduces symptoms of depression, and improves memory and attention, particularly in cases of age-related memory impairment. Additionally, Selank has immune-regulating properties that reduce inflammatory responses and enhance antiviral capabilities, making it effective in improving symptoms of post-COVID-19 asthenia and immune disorders such as atopic dermatitis.
$55
$69
Quantity
ADD TO CART
BUY IT NOW
  • Detail

    Research Peptide · For Laboratory Use Only

    Selank 5mg

    Tuftsin Analog · Anxiolytic & Nootropic Heptapeptide · Lyophilized Powder · Purity ≥99% (HPLC)

    Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It was designed as a metabolically stable analog of tuftsin — the endogenous immunomodulatory tetrapeptide Thr-Lys-Pro-Arg released from immunoglobulin G — by extending its C-terminus with the protective Pro-Gly-Pro fragment.

    Developed at the Russian Academy of Sciences' Institute of Molecular Genetics (the same research program that produced Semax), Selank has been studied for decades for its pronounced anxiolytic and nootropic profile — relieving anxiety and stress-related disturbances while enhancing cognition, without the sedative, muscle-relaxant or dependence-forming effects typical of benzodiazepines. Each vial is supplied as a sterile lyophilized (freeze-dried) powder to ensure maximum stability.

    Product Specifications

    Product Name Selank (Tuftsin Analog, PL-14736)
    CAS Number 129954-34-3 (tuftsin itself: 63491-95-2)
    Amino Acid Sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP, 7 residues; tuftsin core Thr-Lys-Pro-Arg extended with the Pro-Gly-Pro stabilizing fragment)
    Molecular Formula C₃₃H₅₇N₁₁O₉
    Molecular Weight 751.88 g/mol
    Activity Profile Anxiolytic and nootropic; no sedative or dependence-forming profile in research models
    Quantity 5mg per vial
    Physical Form White to off-white lyophilized powder
    Purity ≥99% as determined by HPLC
    Storage -20°C for long term; 2–8°C for short term (lyophilized)

    What is Selank?

    Tuftsin is a naturally occurring tetrapeptide (Thr-Lys-Pro-Arg) released by enzymatic cleavage of immunoglobulin G, where it stimulates phagocytosis and immune cell activity. In the 1990s, researchers at the Russian Academy of Sciences set out to engineer tuftsin analogs with enhanced stability and central nervous system activity — and Selank emerged from this program as the lead compound.

    The key design insight was appending the Pro-Gly-Pro fragment to the tuftsin core: this C-terminal extension dramatically slows enzymatic degradation, extending the peptide's duration of action while preserving (and even broadening) its biological profile.

    In published research, Selank has been investigated in a wide range of settings, including:

    • Anxiety research — Selank has been studied in generalized anxiety disorder and neurasthenia models, with pronounced anxiolytic effects reported;
    • Stress and emotional-behavioral models, including inbred mouse strains with genetically high anxiety;
    • Cognitive enhancement and nootropic research (learning, memory, attention);
    • Ethanol-induced and age-related memory disturbance studies, where the tuftsin analog showed protective effects;
    • Immunomodulation research, reflecting its tuftsin heritage — including modulation of inflammation-related gene expression in immune tissues.

    With an established clinical history as an anxiolytic nasal preparation in Russia and a growing international research literature, Selank stands as one of the most thoroughly studied peptide anxiolytics — a benchmark compound for research into non-benzodiazepine anxiety modulation.

    Mechanism of Action

    1. Modulation of the GABAergic System

    Selank's anxiolytic effects are closely linked to modulation of the GABA-A receptor system — the principal inhibitory neurotransmission pathway targeted by anxiolytics — but research models report anxiolysis without the accompanying sedation, muscle relaxation or withdrawal phenomena characteristic of benzodiazepines.

    2. Inhibition of Enkephalin Degradation

    Selank inhibits enkephalin-degrading enzymes, prolonging the action of endogenous opioid peptides (enkephalins) involved in stress adaptation and emotional regulation — considered a primary contributor to its anxiolytic and antistress profile.

    3. Transcriptomic & Neurotransmitter Regulation

    Gene expression studies show that Selank modulates the transcription of genes involved in neurotransmission, synaptic plasticity and stress response in the brain, and influences serotonergic and dopaminergic signaling — a broad molecular footprint underlying its combined anxiolytic–nootropic profile.

    4. Immunomodulation via Tuftsin Heritage

    As a tuftsin analog, Selank retains immunomodulatory properties: studies report altered expression of cytokines, chemokines and their receptors in immune tissues under Selank administration, linking nervous and immune system modulation.

    5. Active Metabolite: Pro-Gly-Pro (PGP)

    Enzymatic degradation of Selank generates the stable C-terminal tripeptide Pro-Gly-Pro, which itself exhibits neuroprotective and behavioral activity — meaning Selank delivers both parent-compound and metabolite effects, a feature shared with its sibling peptide Semax.

    Handling & Storage Guidelines

    • Lyophilized powder: Store at -20°C for long-term stability; 2–8°C is acceptable for short-term storage. Avoid repeated temperature cycling and protect from moisture.
    • Before opening: Allow the vial to reach room temperature and briefly centrifuge to ensure the full contents collect at the bottom of the vial.
    • Reconstitution: Selank dissolves readily in water or physiological saline. Add solvent gently along the vial wall and swirl slowly until fully dissolved; avoid vigorous shaking.
    • Reconstituted solution: Store at 2–8°C and use promptly; aliquot if needed and avoid repeated freeze-thaw cycles.
    • General: Handle with standard laboratory protective equipment (gloves, lab coat, eye protection).

    Why Choose Our Selank?

    🧪

    Verified Purity

    Each batch tested by HPLC & MS; COA available upon request.

    📦

    Secure Packaging

    Sealed vials with temperature-protective packaging for safe delivery.

    🚚

    Fast Dispatch

    Orders processed promptly with tracking provided.

    Frequently Asked Questions

    Q1: What is the difference between Selank and Semax?

    A: Both are synthetic heptapeptides developed by the same Russian Academy of Sciences research program and both share the metabolically stabilizing Pro-Gly-Pro C-terminus, but they derive from different parent molecules and serve different research purposes. Semax is an ACTH(4–10) analog studied mainly for neuroprotection and cognition, while Selank is a tuftsin analog studied mainly for anxiolytic (anti-anxiety) and antistress effects.

    Q2: What is the difference between Selank and N-Acetyl Selank?

    A: N-Acetyl Selank carries an additional acetyl group on its N-terminal threonine, which further improves resistance to enzymatic degradation. The core pharmacological profile (anxiolytic and nootropic) is considered similar; the acetylated form is simply a more metabolically stable variant.

    Q3: How should I store it after receiving?

    A: Keep unopened vials at -20°C for long-term storage. Once reconstituted, refrigerate at 2–8°C and use promptly; aliquot and avoid repeated freeze-thaw cycles.

    Q4: Is a Certificate of Analysis (COA) available?

    A: Yes, third-party tested COA documentation can be provided for each batch. Please contact our customer service with your order number.

    ⚠ Research Use Only — Disclaimer

    All product information provided on this page is solely for information dissemination and educational purposes. The products offered are intended exclusively for in vitro laboratory research and are not pharmaceuticals. They have not been approved by the U.S. Food and Drug Administration (FDA) or any other regulatory authority for the purposes sold here, and must not be used to prevent, treat or cure any medical condition, disease or ailment.

    It is strictly prohibited to introduce these products into the human or animal body in any form. By purchasing, the buyer acknowledges full responsibility for the proper handling, use and compliance with all applicable local laws and regulations.

  • Customer Reviews
    No comments