PEG MGF 2MG

PEG-MGF 2mg — PEGylated Mechano Growth Factor for Research

PEG-MGF (PEGylated Mechano Growth Factor) is a modified research peptide derived from Mechano Growth Factor (MGF), a splice variant of Insulin-like Growth Factor-1 (IGF-1, IGF-1Ec isoform). Native MGF is preferentially expressed in response to mechanical stress and tissue damage, playing a distinct role in cellular repair and regeneration — particularly in skeletal muscle tissue.

Because unmodified MGF has a remarkably short half-life in biological systems (measured in minutes), PEG-MGF is created by covalently attaching polyethylene glycol (PEG) chains to the native MGF sequence. This modification significantly extends the peptide's stability and activity duration while preserving its core biological activity — making it a more practical tool for laboratory investigation of MGF signaling.

Each vial contains 2mg of PEG-MGF, supplied as a sterile lyophilized (freeze-dried) powder to ensure maximum stability and long-term storage integrity.

▎Product Specifications

▎Research Highlights

• Extended Half-Life vs. Native MGF: Native MGF is cleared within minutes in biological systems. PEGylation extends the peptide's activity duration significantly, making it suitable for longer research protocols and reducing dosing frequency in experimental settings.
• Preserved Bioactivity: Laboratory studies indicate that the PEG modification preserves the peptide's receptor binding affinity and its ability to activate IGF-1 receptor-associated signaling pathways.
• Enhanced Proteolytic Resistance: PEG-MGF demonstrates improved resistance to enzymatic degradation compared to unmodified MGF, facilitating long-term investigation of MGF signaling in cellular models.
• Satellite Cell & Muscle Repair Research: MGF is studied for its role in satellite cell activation and myoblast proliferation — key processes in skeletal muscle repair and regeneration research.
• Mechanically-Induced Isoform: As the IGF-1 splice variant expressed in response to mechanical stress and tissue damage, MGF is a compound of broad interest in exercise physiology and tissue repair studies.

▎Mechanism of Action (Summary)

PEG-MGF operates through mechanisms closely paralleling native Mechano Growth Factor:

• Binding to IGF-1 receptors on target cells, initiating intracellular signaling cascades;
• Activation of the PI3K/Akt signaling pathway, associated with cellular survival, growth, protein synthesis, and metabolic regulation;
• Stimulation of satellite cell activation and myoblast proliferation, key processes in muscle tissue research;
• Sustained receptor engagement provided by PEGylation, enabling signaling duration not achievable with native MGF in experimental protocols.

▎Storage & Handling

Quality Assurance

Every batch of PEG-MGF is verified by HPLC for purity and Mass Spectrometry (MALDI-TOF) for molecular weight and PEGylation confirmation. A Certificate of Analysis (COA) is provided with each order, and independent third-party testing reports are available upon request.

Important Notice — Research Use Only

All product information on this page is provided solely for informational and educational purposes. The products offered are intended exclusively for laboratory and in vitro research. They are not pharmaceuticals, have not been approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, prevent, treat, or cure any medical condition. These products must not be administered to humans or animals. By purchasing, you confirm that you are a qualified researcher and that the product will be used only for lawful research purposes.