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  • NAD NJ100 NJ500 NJ1000
  • NAD NJ100 NJ500 NJ1000
  • NAD NJ100 NJ500 NJ1000

NAD NJ100 NJ500 NJ1000

This product is supplied as Research Use Only (RUO) material for laboratory and scientific research applications.
NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme involved in cellular energy diabetes, mitochondrial function, and biological oxidation-reduction processes. It is widely studied in fields including cellular biology, aging research, diabetes, and molecular mechanisms of energy production. The 1000mg specification provides researchers with sufficient material for advanced laboratory studies, analytical testing, and formulation research.
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    NAD+ 500mg — Nicotinamide Adenine Dinucleotide for Research

    NAD+ (Nicotinamide Adenine Dinucleotide), also known as Coenzyme I (β-NAD / DPN), is a dinucleotide coenzyme found in all living cells and central to cellular metabolism. It consists of two nucleotides — one carrying a nicotinamide group and one carrying an adenine group — joined through their phosphate groups.

    As a key electron carrier, NAD+ cycles between its oxidized form (NAD+) and reduced form (NADH), participating in hundreds of enzymatic redox reactions including glycolysis, the tricarboxylic acid (TCA) cycle, fatty acid oxidation, and oxidative phosphorylation. Beyond energy metabolism, NAD+ serves as an essential substrate for signaling enzymes such as sirtuins and PARP family proteins, linking cellular energy status to DNA repair, gene expression, and aging-related pathways.

    Each vial contains 500mg of NAD+, supplied as a white to off-white crystalline powder of research-grade quality.

    ▎Product Specifications

    Product Name NAD+ (β-Nicotinamide Adenine Dinucleotide)
    Synonyms Coenzyme I; β-NAD; β-DPN; DPN; Cozymase
    Molecular Formula C21H27N7O14P2
    Molecular Weight 663.43 g/mol
    CAS Number 53-84-9
    PubChem CID 10897651
    Appearance White to off-white crystalline powder
    Melting Point 140–142°C
    Solubility Soluble in water
    Quantity 500mg / vial
    Purity ≥99% as determined by HPLC
    Certificate of Analysis COA available upon request / downloadable

    ▎Research Highlights

    • Central Role in Cellular Energy Metabolism: NAD+ is an essential electron carrier in glycolysis, the TCA cycle, fatty acid β-oxidation, and oxidative phosphorylation — the core pathways by which cells convert nutrients into ATP.
    • Substrate for Sirtuins: NAD+ is the required co-substrate for sirtuin deacetylases (SIRT1–7), a protein family implicated in the regulation of aging, metabolism, and cellular stress responses.
    • DNA Repair via PARPs: Poly(ADP-ribose) polymerases (PARPs), key enzymes in DNA damage repair, consume NAD+ as their substrate, linking NAD+ availability to genome maintenance.
    • Age-Related Decline Research: Cellular NAD+ levels have been observed to decline with age, making NAD+ metabolism and its precursors a major focus of aging and longevity research.
    • Redox Homeostasis: The NAD+/NADH ratio is a fundamental determinant of cellular redox state and metabolic balance, widely used as a readout in metabolic research.

    ▎Mechanism of Action (Summary)

    NAD+ participates in cellular function through two principal mechanisms:

    • Redox coenzyme: NAD+ accepts electrons (as a hydride ion) from metabolic substrates to form NADH, shuttling reducing equivalents between catabolic and anabolic pathways;
    • Enzyme substrate: NAD+ is consumed by sirtuins (deacetylation coupled to ADP-ribosylation), PARPs (poly-ADP-ribosylation in DNA repair), and CD38/CD157 ectoenzymes (calcium signaling), coupling cellular NAD+ availability to gene regulation, genome stability, and signal transduction.

    ▎Storage & Handling

    Powder Storage Store at −20°C, sealed, dry and protected from light. NAD+ is hygroscopic; minimize exposure to ambient moisture.
    Solution Preparation Dissolve in sterile water. NAD+ solutions are more stable under slightly acidic conditions; avoid prolonged storage at neutral or alkaline pH.
    After Reconstitution Aliquot and store solutions at −20°C for longer-term use; use freshly prepared solutions whenever possible. Avoid repeated freeze-thaw cycles.
    Handling Notes Allow vial to reach room temperature before opening to reduce moisture uptake. Handle with standard laboratory protective equipment.

    Quality Assurance

    Every batch of NAD+ is verified by HPLC for purity and characterized for identity and molecular weight. A Certificate of Analysis (COA) is provided with each order, and independent third-party testing reports are available upon request.

    Important Notice — Research Use Only

    All product information on this page is provided solely for informational and educational purposes. The products offered are intended exclusively for laboratory and in vitro research. They are not pharmaceuticals, have not been approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, prevent, treat, or cure any medical condition. These products must not be administered to humans or animals. By purchasing, you confirm that you are a qualified researcher and that the product will be used only for lawful research purposes.

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