MOTS-C 10MG 20MG 30MG 40MG
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Detail
MOTs-C 10mg — Mitochondrial-Derived Peptide for Research
MOTs-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide consisting of 16 amino acids, encoded by the 12S rRNA region of the mitochondrial genome. It has attracted significant research interest for its role in metabolic regulation, cellular stress responses, and mitochondria–nucleus communication.
Each vial contains 10mg of MOTs-C, supplied as a sterile lyophilized (freeze-dried) powder to ensure maximum stability and long-term storage integrity.
▎Product Specifications
Product Name MOTs-C (Human) Amino Acid Sequence MRWQEMGYIFYPRKLR Molecular Formula C101H152N28O22S2 Molecular Weight 2174.6 g/mol CAS Number 1627580-64-6 PubChem CID 146675088 Quantity 10mg / vial Form Lyophilized powder Purity ≥99% as determined by HPLC Certificate of Analysis COA available upon request / downloadable ▎Research Highlights
- AMPK Activation & Metabolic Regulation: MOTs-C activates AMPK (AMP-activated protein kinase), regulating key metabolic pathways including fatty acid oxidation and gluconeogenesis, which is essential for maintaining glucose homeostasis in research models.
- Cellular Stress Response: Under oxidative stress or nutrient deprivation, MOTs-C expression changes and activates intracellular stress signaling pathways, enhancing cellular stress resistance and inducing antioxidant enzyme expression.
- Anti-inflammatory & Antioxidant Properties: Published studies indicate that MOTs-C can inhibit the production of inflammatory mediators and reduce oxidative stress, making it a compound of interest in cardiovascular and metabolic research.
- Mitochondria–Nucleus Communication: MOTs-C can interact with transcription factors and regulatory elements of nuclear DNA, directly regulating nuclear gene expression — a distinctive feature among mitochondria-derived peptides.
- Aging-Related Research: Circulating MOTs-C levels have been observed to decline with age, and the peptide is under investigation in research on age-related metabolic conditions.
▎Mechanism of Action (Summary)
Research to date has identified several pathways through which MOTs-C exerts its biological effects:
- Activation of the AICAR–AMPK signaling pathway, modulating expression of genes such as GLUT4, STAT3, and IL-10;
- Promotion of GLUT4 translocation and glucose uptake, a process shown to require mitochondrial fusion (OPA1 / MFN2);
- Interaction with STAT3 via a putative SH2 binding motif in the YIFY region, enhancing myotube formation in muscle progenitor cell models;
- Regulation of mitochondrial biogenesis markers (TFAM, COX4, NRF1) and mitochondrial dynamics.
▎Storage & Handling
Lyophilized Powder Store at −20°C, dry and protected from light. Under these conditions the peptide is stable for up to 24 months. After Reconstitution Reconstitute with bacteriostatic water or appropriate solvent. Reconstituted solutions should be stored at 2–8°C and used promptly. Avoid repeated freeze-thaw cycles. Handling Notes Centrifuge briefly before opening to recover all contents. Handle with standard laboratory protective equipment. Quality Assurance
Every batch of MOTs-C is verified by HPLC for purity and Mass Spectrometry for molecular weight confirmation. A Certificate of Analysis (COA) is provided with each order, and independent third-party testing reports are available upon request.
Important Notice — Research Use Only
All product information on this page is provided solely for informational and educational purposes. The products offered are intended exclusively for laboratory and in vitro research. They are not pharmaceuticals, have not been approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, prevent, treat, or cure any medical condition. These products must not be administered to humans or animals. By purchasing, you confirm that you are a qualified researcher and that the product will be used only for lawful research purposes.
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