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Melanotan 10mg

The peptide will be provided as lyophilized powder to ensure maximum stability.
Melanota is a synthetic metabolic peptide. It stimulates melanocytes to accelerate melanin production, thus speeding up tanning. Even with low UV exposure, it can quickly darken the skin and achieve the desired tanning effect. Additionally, it helps reduce UV-induced skin damage and lowers the risks of skin cancer and sunburn. Melanota also interacts with appetite-regulating receptors to assist in weight control. Clinical trials have demonstrated its ability to enhance male erections and libido, as well as increase female libido, making it a potential treatment for sexual dysfunction. For fair-skinned individuals, it provides a safer and more effective tanning method. Moreover, it strengthens the skin's natural defense, reduces UV-caused damage, and thus offers partial protection for skin health.
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    Melanotan II (MT-2) 10mg — Synthetic α-MSH Analog for Research

    Melanotan II (MT-II / MT-2) is a synthetic cyclic heptapeptide analog of the naturally occurring melanocortin peptide hormone α-melanocyte-stimulating hormone (α-MSH). Originally developed at the University of Arizona, it is the most widely studied member of the melanotan family and a classic tool compound in melanocortin receptor research.

    The peptide's constrained cyclic structure — formed by a lactam bridge between the Asp and Lys residues — confers enhanced receptor binding affinity, metabolic stability, and potency compared with the native linear α-MSH, making Melanotan II a valuable reference compound for structure–activity relationship (SAR) studies of the melanocortin receptor family.

    Each vial contains 10mg of Melanotan II, supplied as a sterile lyophilized (freeze-dried) powder to ensure maximum stability and long-term storage integrity.

    ▎Product Specifications

    Product Name Melanotan II (MT-2 / MT-II)
    Amino Acid Sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 (cyclic heptapeptide)
    Cyclization Lactam bridge between Asp and Lys side chains
    Molecular Formula C50H69N15O9
    Molecular Weight 1024.18 g/mol
    CAS Number 121062-08-6
    PubChem CID 92432
    Quantity 10mg / vial
    Form Lyophilized powder
    Purity ≥99% as determined by HPLC
    Certificate of Analysis COA available upon request / downloadable

    ▎Research Highlights

    • Potent Melanocortin Receptor Agonist: Melanotan II is a non-selective agonist of melanocortin receptors (MC1R, MC3R, MC4R, MC5R) with substantially higher potency than native α-MSH, making it a standard tool compound in receptor pharmacology.
    • Melanogenesis Research: Through MC1R activation on melanocytes, Melanotan II stimulates melanin synthesis and has been widely used to study pigmentation pathways in cellular and animal models.
    • Constrained Cyclic Design: The lactam-bridged cyclic backbone stabilizes the bioactive β-turn conformation, a landmark example in conformationally constrained peptide drug design and SAR studies.
    • Energy Homeostasis Studies: As an MC3R/MC4R agonist, Melanotan II is investigated in research on central regulation of appetite, energy expenditure, and body weight.
    • Enhanced Metabolic Stability: Compared with linear α-MSH, the cyclic structure provides improved resistance to enzymatic degradation, supporting longer-duration experimental protocols.

    ▎Mechanism of Action (Summary)

    Melanotan II mimics endogenous α-MSH signaling through the melanocortin receptor family:

    • Binds and activates melanocortin receptors (G protein-coupled receptors), with activity at MC1R, MC3R, MC4R, and MC5R subtypes;
    • MC1R activation on melanocytes upregulates melanin production (eumelanogenesis), the basis of its pigmentation research applications;
    • MC3R / MC4R activation in the central nervous system modulates appetite and energy balance pathways;
    • Receptor activation couples to Gs protein signaling, increasing intracellular cAMP and triggering downstream second-messenger cascades.

    ▎Storage & Handling

    Lyophilized Powder Store at −20°C, dry and protected from light. Under these conditions the peptide is stable for up to 24 months.
    After Reconstitution Reconstitute with bacteriostatic water or appropriate solvent. Reconstituted solutions should be stored at 2–8°C and used promptly. Avoid repeated freeze-thaw cycles.
    Handling Notes Centrifuge briefly before opening to recover all contents. Handle with standard laboratory protective equipment.

    Quality Assurance

    Every batch of Melanotan II is verified by HPLC for purity and Mass Spectrometry for molecular weight confirmation. A Certificate of Analysis (COA) is provided with each order, and independent third-party testing reports are available upon request.

    Important Notice — Research Use Only

    All product information on this page is provided solely for informational and educational purposes. The products offered are intended exclusively for laboratory and in vitro research. They are not pharmaceuticals, have not been approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, prevent, treat, or cure any medical condition. These products must not be administered to humans or animals. By purchasing, you confirm that you are a qualified researcher and that the product will be used only for lawful research purposes.

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