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  • Kisspeptin-10 5mg 10mg
  • Kisspeptin-10 5mg 10mg

Kisspeptin-10 5mg 10mg

The peptide will be provided as lyophilized powder to ensure maximum stability.
Kisspeptin is a hypothalamic neuropeptide encoded by the KISS1 gene, regulating diverse physiological functions through the GPR54 receptor and serving as a core regulatory molecule of the reproductive axis. Its functions include activating the hypothalamic-pituitary-gonadal axis (HPG axis), driving gonadotropin-releasing hormone (GnRH) secretion, and regulating puberty initiation and gonadal development. It also exhibits potential in regulating energy diabetes and glucose-lipid homeostasis. Kisspeptin can treat reproductive disorders such as hypogonadotropic hypogonadism and hypothalamic amenorrhea by stimulating GnRH to restore gonadotropin secretion. In assisted reproduction, it reduces the risk of ovarian hyperstimulation. Its metabolic regulatory effects drive mechanistic research and therapeutic exploration for obesity and non-alcoholic fatty liver disease, establishing it as a key intervention molecule linking neuroendocrine, reproductive, and metabolic systems.
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    Kisspeptin-10 (Human) 10mg — KISS1R/GPR54 Receptor Agonist for Research

    Kisspeptin-10 (Kp-10) is a synthetic decapeptide amide corresponding to residues 45–54 of metastin, the protein product of the KISS1 gene. It represents the minimal active core sequence shared by all longer kisspeptin fragments (Kp-54, Kp-14, Kp-13) and is the shortest sequence required for full activation of the kisspeptin receptor KISS1R (GPR54).

    The KiSS-1/GPR54 system is a key upstream regulator of the hypothalamic–pituitary–gonadal (HPG) axis, with kisspeptin signaling essential for puberty onset and reproductive function. Kisspeptin-10 also exhibits activity in studies of tumor metastasis suppression, angiogenesis inhibition, and vasoconstriction, making it a valuable tool compound across neuroendocrinology and oncology research.

    Each vial contains 10mg of Kisspeptin-10, supplied as a sterile lyophilized (freeze-dried) powder to ensure maximum stability and long-term storage integrity.

    ▎Product Specifications

    Product Name Kisspeptin-10 (Human)
    Synonyms Kp-10; Metastin (45–54); KiSS-1 peptide fragment
    Amino Acid Sequence H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (10 amino acids, C-terminal amidation)
    Molecular Formula C63H83N17O14
    Molecular Weight 1302.4 g/mol
    CAS Number 374675-21-5
    PubChem CID 25240297
    Quantity 10mg / vial
    Form Lyophilized powder
    Purity ≥99% as determined by HPLC
    Certificate of Analysis COA available upon request / downloadable

    ▎Research Highlights

    • Minimal Active Core of Kisspeptin Signaling: Kp-10 is the shortest kisspeptin fragment retaining full KISS1R (GPR54) agonist activity, making it the definitive tool compound for receptor pharmacology and structure–activity studies.
    • Reproductive Neuroendocrinology Research: Kisspeptin signaling is the principal upstream regulator of GnRH release; Kp-10 is widely used to study puberty onset, the HPG axis, and reproductive endocrinology.
    • Metastasis Suppression Research: The KISS1 gene was originally identified as a metastasis suppressor; kisspeptin receptor activation is investigated in tumor cell invasion and metastasis models.
    • Angiogenesis & Vascular Research: Published studies describe Kp-10 as a vasoconstrictor and inhibitor of angiogenesis, supporting its use in vascular biology research.
    • Comparable Receptor Affinity: Kp-10, Kp-13, and Kp-14 fragments demonstrate similar binding affinity at GPR54, with Kp-10 serving as the minimal reference ligand.

    ▎Mechanism of Action (Summary)

    Kisspeptin-10 exerts its effects primarily through the kisspeptin receptor:

    • Binds and activates KISS1R (GPR54), a G protein-coupled receptor, coupling to Gq/11 protein signaling with phospholipase C activation and intracellular calcium mobilization;
    • In the hypothalamus, KISS1R activation on GnRH neurons stimulates gonadotropin-releasing hormone secretion, the gating step of the HPG axis;
    • The conserved C-terminal RF-amide motif is essential for receptor binding and activation;
    • In non-neuronal systems, KISS1R signaling is studied in tumor cell biology, angiogenesis, and vascular tone regulation.

    ▎Storage & Handling

    Lyophilized Powder Store at −20°C, dry and protected from light. Under these conditions the peptide is stable for up to 24 months.
    After Reconstitution Reconstitute with bacteriostatic water or appropriate solvent. Reconstituted solutions should be stored at 2–8°C and used promptly. Avoid repeated freeze-thaw cycles.
    Handling Notes Centrifuge briefly before opening to recover all contents. Handle with standard laboratory protective equipment.

    Quality Assurance

    Every batch of Kisspeptin-10 is verified by HPLC for purity and Mass Spectrometry for molecular weight confirmation. A Certificate of Analysis (COA) is provided with each order, and independent third-party testing reports are available upon request.

    Important Notice — Research Use Only

    All product information on this page is provided solely for informational and educational purposes. The products offered are intended exclusively for laboratory and in vitro research. They are not pharmaceuticals, have not been approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, prevent, treat, or cure any medical condition. These products must not be administered to humans or animals. By purchasing, you confirm that you are a qualified researcher and that the product will be used only for lawful research purposes.

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