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  • IGF-LR3/1 0.1mg 1mg
  • IGF-LR3/1 0.1mg 1mg

IGF-LR3/1 0.1mg 1mg

The peptide will be provided as lyophilized powder to ensure maximum stability.
IGF-1 LR3 is a synthetic, long-acting optimized analog of insulin-like growth factor 1 (IGF-1). Compared to natural IGF-1, its half-life is significantly extended to 20-30 hours, with biological potency increased approximately threefold. It effectively reduces affinity for IGF-binding proteins while enhancing binding to IGF-1 receptors, thereby efficiently activating the PI3K/Akt and MAPK signaling pathways. This stimulates myoblast proliferation and myofibrillar formation, aiding in the increase of high-quality muscle mass; promotes lipolysis and improves insulin sensitivity; activates osteoblast activity to support skeletal health while accelerating repair and regeneration of tissues like skin and mucosa, providing robust support for cellular growth and tissue renewal. IGF-1 LR3 facilitates cell culture by creating optimal growth environments for tissue engineering research. In animal studies, it has demonstrated potential in alleviating muscular dystrophy and promoting wound healing. It plays a significant role in medical research related to growth disorders, advancing life science studies and exploring tissue repair and metabolic regulation.
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    IGF-1 LR3 1mg — Long [Arg3] IGF-1 for Research

    IGF-1 LR3 (Long R3 IGF-1) is a synthetic 83-amino acid analog of human Insulin-like Growth Factor-1 (IGF-1). It is distinguished from native IGF-1 by two engineered modifications: an arginine-for-glutamic acid substitution at position 3 (the "R3" substitution) and a 13-amino acid N-terminal extension (the "Long" extension, sequence MFPAMPLLSLFVN), bringing the total length to 83 amino acids versus 70 in native IGF-1.

    These modifications give IGF-1 LR3 a substantially reduced affinity for IGF-binding proteins (IGFBPs) — which normally sequester and inactivate native IGF-1 — together with a significantly extended half-life. The result is a more bioavailable, longer-acting IGF-1 receptor agonist widely used as a potent growth stimulus in cell biology, serum-free cell culture, and muscle research.

    Each vial contains 1mg of IGF-1 LR3, supplied as a sterile lyophilized (freeze-dried) powder.

    ▎Product Specifications

    Product Name IGF-1 LR3
    Synonyms Long R3 IGF-1; Long [Arg3] IGF-1; LR3-IGF-1
    Amino Acid Length 83 amino acids (native IGF-1 core + 13-residue N-terminal extension)
    Key Modifications E3R substitution (Glu→Arg at position 3); N-terminal extension MFPAMPLLSLFVN
    Molecular Weight Approx. 9,117.5 Da (≈9.1 kDa)
    CAS Number 946870-92-4
    Source Recombinant (typically E. coli expression)
    Quantity 1mg / vial
    Form Lyophilized powder
    Purity ≥98% as determined by HPLC / SDS-PAGE
    Certificate of Analysis COA available upon request / downloadable

    ▎Research Highlights

    • Potent IGF-1 Receptor Agonist: IGF-1 LR3 activates the IGF-1 receptor (IGF-1R) and its downstream growth and survival signaling, making it a standard tool compound in cell proliferation and differentiation research.
    • Reduced IGFBP Binding: The R3 substitution markedly lowers affinity for IGF-binding proteins, which otherwise sequester native IGF-1 — resulting in greater bioavailability of the free, active ligand.
    • Extended Half-Life: The "Long" N-terminal extension confers a substantially longer half-life than native IGF-1, supporting sustained receptor engagement in experimental protocols.
    • Serum-Free Cell Culture Applications: LR3 IGF-1 is widely used as a potent growth supplement in serum-free and defined media, where it can support cell proliferation and viability at far lower concentrations than insulin.
    • Muscle & Satellite Cell Research: As a long-acting IGF-1 analog, it is investigated in studies of muscle growth, satellite cell activation, and related anabolic signaling pathways.

    ▎Mechanism of Action (Summary)

    • Binds and activates the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase;
    • Triggers the PI3K/Akt pathway (cell survival, protein synthesis, anti-apoptotic signaling) and the Ras/MAPK pathway (cell proliferation);
    • Reduced sequestration by IGFBPs increases the fraction of ligand available for receptor activation;
    • The extended half-life enables sustained signaling compared with the rapid clearance of free native IGF-1.

    ▎Storage & Handling

    Lyophilized Powder Store at −20°C (−80°C for long-term storage), dry and protected from light.
    Reconstitution Reconstitute gently with sterile water or PBS. Avoid vigorous shaking or foaming, which can denature proteins. For working solutions below 100 µg/mL, addition of a carrier protein (e.g., 0.1% BSA) is recommended to reduce surface adsorption.
    After Reconstitution Store reconstituted solutions at 2–8°C for short-term use; for longer storage, aliquot and keep at −20°C or −80°C. Avoid repeated freeze-thaw cycles.
    Handling Notes Centrifuge briefly before opening to recover all contents. Handle with standard laboratory protective equipment.

    Quality Assurance

    Every batch of IGF-1 LR3 is verified by HPLC for purity and Mass Spectrometry for molecular weight confirmation. A Certificate of Analysis (COA) is provided with each order, and independent third-party testing reports are available upon request.

    Important Notice — Research Use Only

    All product information on this page is provided solely for informational and educational purposes. The products offered are intended exclusively for laboratory and in vitro research. They are not pharmaceuticals, have not been approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, prevent, treat, or cure any medical condition. These products must not be administered to humans or animals. By purchasing, you confirm that you are a qualified researcher and that the product will be used only for lawful research purposes.

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