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Detail
GHRP-2 (Pralmorelin) 5mg
The Most Potent Classic GHRP | Ghrelin-Receptor GH Secretagogue Hexapeptide
D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂ · KP-102 · Research Use Only
📈 Peak-GH Champion
Regarded as the most potent member of the traditional GHRP family by peak growth-hormone release in published comparative studies.
🏛 Clinical Heritage
As pralmorelin (KP-102), GHRP-2 is the only GHRP with clinical approval history — authorized in Japan as a diagnostic GH-stimulation agent.
🧬 Ghrelin Mimicry
A potent GHS-R1a agonist that mimics endogenous ghrelin signaling — GH release plus appetite-pathway engagement.
🧊 D-Amino-Acid Stability
D-residues at positions 1, 2 and 5 confer strong resistance to proteolytic degradation in research models.
Product Overview
GHRP-2 (Growth Hormone Releasing Peptide-2), also known by its INN name pralmorelin and developmental code KP-102, is a synthetic hexapeptide with the sequence D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂. It belongs to the GHRP family — non-natural peptides with no structural homology to GHRH that potently stimulate somatotrope GH secretion via the ghrelin / growth-hormone-secretagogue receptor (GHS-R1a).
Among the traditional GHRPs, GHRP-2 is consistently described as the most potent by peak GH release, and it holds a unique position in the family: as pralmorelin it is the only GHRP to have achieved clinical approval, authorized in Japan as a diagnostic agent for growth-hormone stimulation testing. Pharmacological characterization (Doi et al., 2004) showed KP-102's GH-releasing potency equivalent to or exceeding other secretagogues, with robust effects in both animal and human studies.
Each vial contains 5mg of high-purity GHRP-2 as a white to off-white lyophilized powder, supplied strictly for in-vitro and laboratory research use only.
Specifications
Product Name GHRP-2 (Pralmorelin) Synonyms KP-102 · (Des-His¹, D-Ala¹, D-2-Nal²)-GHRP-6 analog · CHRP-2 · Pralmorelin CAS Number 158861-67-7 Amino Acid Sequence D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂ (6 residues, C-terminally amidated; 2-Nal = 2-naphthylalanine) Molecular Formula C45H55N9O6 (free base) Molecular Weight ≈ 818.0 g/mol (free base; ≈ 873 as TFA salt) Net Content 5 mg / vial Appearance White to off-white lyophilized powder Purity ≥ 98% (by HPLC) Solubility Soluble in water / aqueous buffer Storage Store lyophilized at -20°C, protected from light and moisture; refrigerate after reconstitution and use promptly Structure: From GHRP-6 to GHRP-2
🧪 The design logic — GHRP-2 was developed by systematic modification of the GHRP-6 scaffold (His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂). The N-terminal histidine was removed, position 1 was given a D-alanine, and the D-tryptophan at position 2 was replaced with D-2-naphthylalanine (D-2-Nal) — a bulkier aromatic that strengthens receptor engagement.
🛡 Built-in protease resistance — the D-amino acids at positions 1, 2 and 5 make the peptide largely invisible to proteases that evolved to cleave L-configured bonds, extending functional stability in research models.
📊 The potency outcome — these changes produced what comparative studies describe as the strongest peak-GH response in the traditional GHRP family, establishing GHRP-2 as the reference potency compound of the class.
Mechanism of Action
Step What Happens 1. GHS-R1a Binding GHRP-2 binds the ghrelin / growth-hormone-secretagogue receptor 1a (GHS-R1a) at both pituitary and hypothalamic levels — the same receptor engaged by endogenous ghrelin. 2. Potent GH Release Somatotrophs release GH in robust pulses; GHRP-2 acts synergistically with GHRH, producing GH responses exceeding either stimulus alone. 3. HPA & Prolactin Co-Stimulation Unlike selective agonists, GHRP-2 activates the hypothalamo-pituitary-adrenal axis: published studies document cortisol/ACTH and prolactin elevation, particularly at higher doses — a defining pharmacological feature of first-generation GHRPs. 4. Appetite-Pathway Engagement As a ghrelin mimetic, GHRP-2 stimulates food intake in animal models — central administration stimulates eating even without proportional GH responses, making it a standard tool in appetite-circuit research. GHRP-2 vs GHRP-6 vs Ipamorelin
Aspect GHRP-2 (this product) GHRP-6 Ipamorelin Peak GH Potency Strongest of the traditional family High (first-in-human GHRP) Equipotent range, partial agonist Cortisol / ACTH Elevated at higher doses Elevated No significant elevation Prolactin Elevated at higher doses Elevated No significant elevation Appetite Stimulation Strong Strongest in the family Markedly weaker Research Position Potency reference; clinically approved lineage (pralmorelin, Japan) First-generation; appetite-research tool Selectivity benchmark (see our ipamorelin listing) Research Highlights
📖 Doi et al., 2004 — KP-102 Pharmacology
Pharmacological characteristics of KP-102 (GHRP-2) characterized it as a potent synthetic GH secretagogue with GH-releasing potency equivalent to the leading compounds of its class.
📖 Roh et al., 2002 — Family Potency Ranking
"To date, GHRP-2 seems to be the most potent member of the family of GHRPs" — establishing its benchmark position in comparative GH-secretion studies.
📖 Laferrère et al., 2005 (PMC2824650)
GHRP-2, like ghrelin, enhances appetite in human studies — documenting the ghrelin-mimetic feeding effect alongside GH release.
🏛 Pralmorelin Diagnostic Approval (Japan)
GHRP-2 is the only GHRP with clinical approval history: pralmorelin is authorized in Japan as a diagnostic agent for growth-hormone stimulation testing — a regulatory precedent unique in this peptide family.
Research Applications & Compliance Notes
🧬 Growth-axis pharmacology — GHS-R1a agonism, GH-secretion kinetics, and GHRH-synergy designs. 🍽 Appetite-circuit research — ghrelin-mimetic feeding studies (central and peripheral administration models). 🎯 Selectivity comparisons — HPA-axis and prolactin co-stimulation versus ipamorelin-class agonists. 🧪 GHRP structure-activity studies — D-2-Nal scaffold modifications and receptor-engagement assays. Compliance note: GHRP-2 (pralmorelin) is listed under peptide hormones / growth factors on the WADA Prohibited List (category S2), and its misuse in sport is an established detection target with published urinary screening methods. Buyers conducting sports-related research should factor this in.
Reconstitution & Handling
💧 Add sterile or bacteriostatic water slowly down the side of the vial; swirl gently until fully dissolved — do not shake vigorously. 🧪 Aliquot reconstituted solution to avoid repeated freeze-thaw cycles; label each aliquot with batch, concentration and preparation date. 🧊 Lyophilized powder: store frozen (-20°C), protected from light and moisture; reconstituted solution: refrigerate and use within your validated stability window. ⚖️ Handle with aseptic technique and appropriate PPE per your laboratory SOP. Quality Assurance
✔ Lot-specific Certificate of Analysis: HPLC purity confirmation + mass-spectrometry identity verification (expected intact mass ≈ 818 Da for the free-base hexapeptide; confirm salt form per your batch documentation).
✔ Third-party batch testing documentation available upon request.
References & Further Reading
- Doi N, et al. Pharmacological characteristics of KP-102 (GHRP-2), a novel synthetic growth hormone secretagogue. 2004. (Cited 19+)
- Roh SG, et al. Characterization of growth hormone secretion in response to GHRPs. Asian-Australas J Anim Sci. 2002. (GHRP family potency ranking)
- Laferrère B, et al. Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, enhances appetite… PMC2824650. 2005.
- GHRP-2 — ChemicalBook CB1104514 (CAS 158861-67-7, C₄₅H₅₅N₉O₆, FW 817.97; synonyms incl. pralmorelin, KP-102).
- Optoelectronical screening methods for pralmorelin and its metabolite in urine — doping-control detection literature. SPIE Proc. 2018.
Disclaimer: This product is intended exclusively for in-vitro laboratory research use. It is not approved for human or animal use, is not a drug, food, cosmetic, or dietary supplement, and is not intended to diagnose, treat, cure or prevent any disease. All products are supplied strictly for research purposes only. -
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